A series of new N-substituted 5-arylidenerhodanine derivatives (D1-D10) were synthesized starting from 5-arylidenerhodanines. The 5-arylidinerhodanines were reacted with 2-bromo-1,1-dimethoxyethane in presence of potassium hydroxide and dimethyl formamide under microwave conditions to give N-substituted 5-arylidenerhodanine derivatives. The synthesized compounds were confirmed on the basis of spectral data and elemental analyses. The newly synthesized compounds were tested for cytotoxicity by brine shrimp lethality bioassay. The N-substituted 5-arylidenerhodanine derivatives (D7, D5 and D6) were proven to be the best potent cytotoxic agents.
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